Лечебное голодание

Эта неспособность раковых клеток должным образом реагировать на экстремальные изменения окружающей среды, таким образом, обеспечивает механизм для улучшения лечения рака путем избирательного повышения стрессоустойчивости только в нормальных клетках (дифференциальная стрессоустойчивость, DSR). DSR у мышей и клеточных линий частично опосредуется снижением уровня IGF-1.ЗаключениеЛечебное голодание является признанным методом лечения, применяемым в специализированных больницах или отделениях натуропатической, интегративной и диетологической медицины в различных странах Центральной Европы и США.Лечение голодом основано на добровольном кратковременном отказе от пищи. В этот период организм переходит на эндогенное питание – питание за счет собственных резервов. В результате происходит перестройка обменных процессов и запускается режим восстановления и очищения. Также наблюдается нормализация/снижение массы тела пациента.Однако, голодание – это, прежде всего, метод комплексного лечения организма, и только во вторую очередь – способ снижения веса. Многочисленные исследования доказывают, что с помощью различных методов голодания успешно лечится широкий спектр заболеваний.Список литературыBrecchia G, Bonanno A, Galeati G, Federici C, Maranesi M, Gobbetti A, Zerani M, Boiti C: Hormonal and metabolic adaptation to fasting: effects on the hypothalamic-pituitary-ovarian axis and reproductive performance of rabbit does. DomestAnimEndocrinol2006;31:105–122.Buchinger A: Fasting; in Nowey D (ed): Clinician’s Complete Reference to Complementary and Alternative Medicine. Chicago, Mosby, 2002.Buchinger O: Therapeutic fasting and its auxiliary methods. Stuttgart, Hippokrates, 1932.Darlington LG, Ramsey NW, Mansfield JR: Placebo-controlled, blind study of dietary manipulation therapy in rheumatoid arthritis. Lancet1986;1:236– 238.de los Santos-Arteaga M, Sierra-Dominguez SA, Fontanella GH, Delgado-Garcia JM, Carrion AM: Analgesia induced by dietary restriction is mediated by the kappa-opioid system. J Neurosci 2003;23: 11120–11126.Fontana L, Partridge L, Longo VD: Extending healthy life span – from yeast to humans. Science2010;328:321–326.Goehler L, Hahnemann T, Michael N, Oehme P, Steglich HD, Conradi E, Grune T, Siems WG: Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding. PrevMed2000;30:95–102.Hall JA, Dominy JE, Lee Y, Puigserver P: The sirtuin family’s role in aging and age-associated pathologies. J ClinInvest2013;123:973–979.Hargraves WA, Hentall ID: Analgesic effects of dietary caloric restriction in adult mice. Pain 2005; 114:455–461.Holloszy JO: Mortality rate and longevity of foodrestricted exercising male rats: a reevaluation. J ApplPhysiol1997;82:399–403.Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y: IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature2003;421:182–187Horowitz JF, Coppack SW, Paramore D, Cryer PE, Zhao G, Klein S: Effects of short-term fasting on lipid kinetics in lean and obese woman. Am J Physiol 1999;276:E278–284.Kim HG, Lim EY, Jung WR, Shin MK, Ann ES, Kim KL: Effects of treadmill exercise on hypoactivity of the hypothalamo-pituitary-adrenal axis induced by chronic administration of corticosterone in rats. NeurosciLett2008;434:46–49.Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Forre O: Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet1991;338:899– 902Knott PJ, Joseph MH, Curzon G: Effects of food deprivation and immobilization on tryptophan and other amino acids in rat brain. J Neurochem 1973; 20:249–251.Kouda K, Iki M: Beneficial effects of mild stress (hormetic effects): dietary restriction and health. J PhysiolAnthropol2010;29:127–132.Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N: The role of autophagy during the early neonatal starvation period. Nature2004;432:1032–1036.Lee C, Longo VD: Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene 2011;30: 3305–3316Lützner H: Fasting/fasting therapy: basic principles and methodology; in Bühring M, Kemper FH, Matthiessen PF (eds): Naturheilverfahren und UnkonventionelleMedizinischeRichtungen. Berlin, SpringerLoseblattSysteme, 1998, pp 1-26.Merry BJ: Oxidative stress and mitochondrial function with aging – the effects of calorie restriction. AgingCell2004;3:7–12.Michalsen A, Kuhlmann MK, Lüdtke R, Bäcker M, Langhorst J, Dobos GJ: Prolonged fasting in patients with chronic pain syndromes leads to late mood-enhancement not related to weight loss and fasting-induced leptin depletion. NutrNeurosci2006;9:195–200Michalsen A, Li C, Kaiser K, Lüdtke R, Meier L, Stange R, Kessler C: In-patient treatment of fibromyalgia: a controlled nonrandomized comparison of conventional medicine versus integrative medicine including fasting therapy. EvidBasedComplementAlternatMed2013;2013:908610.Michalsen A, Riegert M, Lüdtke R, Bäcker M, Langhorst J, Schwickert M, Dobos GJ: Mediterranean diet or extended fasting’s influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: an observational study. BMC ComplementAlternMed2005;5:22.Michalsen A, Schneider S, Rodenbeck A, Lüdtke R, Huether G, Dobos GJ: The short-term effects of fasting on the neuroendocrine system in patients with chronic pain syndromes. NutrNeurosci2003;6:11–18.Michalsen A: Prolonged fasting as a method of mood enhancement in chronic pain syndromes: a review of clinical evidence and mechanisms. CurrPainHeadacheRep2010;14:80–87.Müller H, Wilhelmi de Toledo F, Resch KL: Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scand J Rheumatol2001;30:1–10.Owen OE, Smalley KJ, D’Alessio DA, Mozzoli MA, Dawson EK: Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis. Am J ClinNutr1998;68:12–34.Park S, Sohn S, Kineman RD: Fasting-induced changes in the hypothalamic-pituitary-GH axis in the absence of GH expression: lessons from the spontaneous dwarf rat. J Endocrinol2004;180:369–378.Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD: Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. ProcNatlAcadSci USA 2008;105:8215–8220.Ramsey JJ, Colman RJ, Binkley NC, Christensen JD, Gresl TA, Kemnitz JW, Weindruch R: Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. ExpGerontol2000;35:1131–1149.Ristow M, Schmeisser S: Extending life span by increasing oxidative stress. FreeRadicBiolMed2011;51:327–336.Schmidt S, Stange R, Lischka E, Kiehntopf M, Deufel T, Loth D, Uhlemann C: Uncontrolled clinical study of the efficacy of ambulant fasting in patients with osteoarthritis. ForschKomplementmed2010;17:87–94.Schweiger U, Broocks A, Tuschl RJ, Pirke KM: Serotonin turnover in rat brain during semistarvation with high-protein and high-carbohydrate diets. J NeuralTransm1989;77:131–139.Sell DR: Ageing promotes the increase of early glycation Amadori product as assessed by epsilonN-(2-furoylmethyl)-L-lysine (furosine) levels in rodent skin collagen. The relationship to dietary restriction and glycoxidation. Mech Ageing Dev 1997; 95:81–99.Shelton H: The Hygienic System: Fasting and Sun Bathing. San Antonio, Dr. Shelton’s Health School, 1963.Sköldstam L, Larsson L, Lindström FD: Effect of fasting and lactovegetarian diet on rheumatoid arthritis. Scand J Rheumatol1979;8:249–255.Uden AM, Trang L, Venizelos N, Palmblad J: Neutrophil functions and clinical performance after total fasting in patients with rheumatoid arthritis. AnnRheumDis1983;42:45–51.Varady KA, Ebine N, Vanstone CA, Parsons WE, Jones PJ: Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 wk. Am J ClinNutr 2004;80:1159–1166.Varady KA, Hellerstein MK: Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J ClinNutr2007;86:7–13.Varela A, Marina Prendes MG, Testoni G, Vazquez N, Astudilla C, Cerruti S, Savino EA: Influence of fasting on the effects of ischemic preconditioning in the ischemic-reperfused rat heart. ArchPhysiolBiochem2002;110:189–196.